Osteoporosis
Halma M, O'Leary C, Varon J. Herbal and nutraceutical interventions for osteoporosis: a review of effects on bone mineral density. Journal of Clinical Rheumatology and Immunology. 2025. doi: 10.1142/S2661341725300010
- Rehmannia glutinosa
- Cornus mas (cornelian cherry)
- Genistein (soy isoflavone)
- Rhizoma drynariae (Gu Sui Bu)
- Selenium
- Magnesium
- Vitamin C
- Calcium + Vitamin D
Post-Acute COVID/Vaccination Syndrome (PACVS)
Halma M, Varon J. Metabolic modulation as a therapeutic strategy for post-acute vaccination syndrome (PACVS): a review of pathomechanisms and existing therapeutic components. Biomedicine & Pharmacotherapy. 2025;193:118864. doi: 10.1016/j.biopha.2025.118864
- N-acetylcysteine (NAC)
- NMN / NADβΊ precursors
- Vitamin C (high-dose)
- Taurine
- Acetyl-L-carnitine
- Creatine
- L-Citrulline
- Low-dose naltrexone (LDN)
- Methylene blue
- Coenzyme Q10
- GLP-1 receptor agonists
Measles
Kaur A, Alaribe U, Varon J, Hassaan S, Halma M. Acute management of measles: a systematic review of therapeutic strategies. Antiviral Research. 2026;247:106361. doi: 10.1016/j.antiviral.2026.106361
- Vitamin A (high-dose supplementation)
- Ribavirin
- Interferon-Ξ±
- Zinc supplementation
- Investigational monoclonal antibodies
Depression
Halma M, Levy R, Varon J. With great power comes great responsibility: promise and caution in the new psychedelic renaissance. Brain Disorders. 2025;20:100286. doi: 10.1016/j.dscb.2025.100286
Halma M, Plothe C, Marik PE. Integrative interventions for improving outcomes in depression: a narrative review. Psychology International. 2024;6(2):33. doi: 10.3390/psycholint6020033
- Omega-3 fatty acids (EPA/DHA)
- Saffron (Crocus sativus)
- St. John's Wort (Hypericum perforatum)
- Curcumin
- Magnesium
- Vitamin D
- SAMe (S-adenosylmethionine)
- Psilocybin
- Ketamine / esketamine
- MDMA-assisted therapy
- Ibogaine
Opioid Use Disorder
Halma M, Hesse C, Selem E, Varon J. Therapeutic potential of herbalism for opioid use disorder. Revista Internacional de Investigación en Adicciones. 2025;11(1):71-78. [link]
Halma M, Varon J, Dhillon S, Selem E, Gracidas C, Levy R. Improving outcomes in psychedelic-assisted therapy for opioid addiction through herbal medicine. Medical Research Archives. 2026;14(3). doi: 10.18103/mra.v14i3.7337
- Ibogaine
- Corydalis (Yan Hu Suo)
- Saffron / Crocin
- Berberine
- Nigella sativa (black seed)
- Berberis vulgaris (barberry)
- Matricaria chamomilla (chamomile)
- Sophora alopecuroides (matrine)
- Tai-Kang Ning (traditional formula)
- Fu-Yuan Pellet (traditional formula)
Cancer
Halma M, Tuszynski JA. Cancer metabolism as a therapeutic target and review of interventions. Nutrients. 2023;15(19):4245. doi: 10.3390/nu15194245
- Lifestyle & Metabolic
- Ketogenic diet / glucose management
- Exercise (30 min/day)
- Stress reduction
- Sleep optimization (7β8 h)
- Natural Agents β Stronger Evidence
- Vitamin D
- Melatonin
- Green tea catechins (EGCG)
- Curcumin
- Omega-3 fatty acids
- Berberine
- Mistletoe extract (Viscum album)
- Ashwagandha (Withania somnifera)
- Natural Agents β Equivocal Evidence
- Resveratrol
- Fermented wheat germ extract
- Nigella sativa (thymoquinone)
- Reishi mushroom
- IV Vitamin C
- Cannabinoids (CBD/THC)
- Pao Pereira
COPD
Halma MTJ, Saleeby Y, Tuszynski J. Herbal medicine for COPD. Authorea. 04 November 2024. doi: 10.22541/au.172605614.42962063/v2
- Astragalus membranaceus (Huang Qi)
- Rhodiola rosea
- Nanocurcumin
- Withania somnifera (Ashwagandha)
- Panax ginseng
- L-Carnitine
- Cordyceps sinensis
- N-acetylcysteine (NAC)
- Resveratrol
- Glycyrrhiza glabra (licorice root)
- Thymoquinone (Nigella sativa)
- Ivy leaf extract (Hedera helix)
- Crocin / Saffron
Dementia & Cognitive Aging
Halma M, Marik P, Gazda S, Tuszynski J. Lifestyle medicine for healthy cognitive aging: a narrative review. Brain, Behavior, and Immunity – Integrative. 2024;7:100077. doi: 10.1016/j.bbii.2024.100077
- Mediterranean / MIND dietary pattern
- Aerobic + resistance exercise
- Sleep optimization (7β9 hours)
- Stress management (mindfulness / meditation)
- Social engagement
- Cognitive stimulation activities
- Omega-3 fatty acids (EPA/DHA)
- Curcumin
- Vitamin D + B-vitamins (B6, B12, folate)
Sarcopenia
Halma M, Marik P, Varon J, Tuszynski J. Reversing decline in aging muscles: expected trends, impacts and remedies. Journal of Functional Morphology and Kinesiology. 2025;10(1):29. doi: 10.3390/jfmk10010029
- Resistance / strength training
- Leucine supplementation
- High-protein diet (β₯1.2 g/kg/day)
- Fish oil / Omega-3 fatty acids
- Selenium supplementation
- Dioscorea esculenta (lesser yam extract)
- Metformin (repurposed)
- Losartan (repurposed)
Anxiety
Halma M, Covarrubias A, Selem E, Varon J. Anxiety: a look at epidemiological factors and alternate treatments. International Journal of Depression and Anxiety. 2025;8:044. doi: 10.23937/2643-4059/1710044
- Ashwagandha
- CBD (cannabidiol)
- Saffron
- CBG (cannabigerol)
- L-Theanine
- Lavender oil
- Magnesium + Vitamin B6
- Rhodiola rosea
- Lemon balm
Hypothyroidism
Santiago JB, Martinez F, Durzynski N, Varon J, Halma M. Herbal treatments for hypothyroidism: an evidence-based review. Journal of Thyroid Disorders & Therapy. 2025;14:360. doi: 10.35841/2167-7948.25.S1.001
- Desiccated Thyroid Extract (DTE)
- Iodine
- Nigella sativa
- L-Carnitine
- Ashwagandha
Insulin Resistance
Halma MTJ, Syed M, Marik PE. Potential dietary and lifestyle interventions for decreasing insulin resistance. Journal of American Physicians and Surgeons. 2023;28(4):120β8. [PDF]
- Time-restricted eating / intermittent fasting
- Berberine
- Metformin
- Magnesium
- Resveratrol
- Cinnamon
- Omega-3 fatty acids
- Melatonin
- Probiotics
Hypertension
Halma M, et al. Herbal antihypertensive interventions: a narrative review. Preprint. 2024. preprints.org/manuscript/202406.0353/v1
- Garlic (Allium sativum)
- Hawthorn (Crataegus spp.)
- Hibiscus sabdariffa (roselle tea)
- Olive leaf extract (oleuropein)
- Coenzyme Q10
- Rauwolfia serpentina / reserpine
- Berberine