Peer-reviewed publications by our team members spanning post-viral syndromes, drug repurposing for chronic disease, and environmental health and drug safety.
Strategies for the Management of Spike Protein-Related Pathology
Halma MTJ, Rose J, Lawrie T. Strategies for the management of spike protein-related pathology. Microorganisms. 2023;11(5):1308. doi: 10.3390/microorganisms11051308
★ #8 most viewed article of all time in Microorganisms out of 18,025 articles (May 2026)Therapeutic Potential of Compounds Targeting SARS-CoV-2 Helicase
Halma MTJ, Wever MJA, Abeln S, Roche D, Wuite GJL. Therapeutic potential of compounds targeting SARS-CoV-2 helicase. Frontiers in Chemistry. 2022;10:1062352. doi: 10.3389/fchem.2022.1062352
Exploring Autophagy in Treating SARS-CoV-2 Spike Protein-Related Pathology
Halma MTJ, Marik PE, Saleeby YM. Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology. Endocrine and Metabolic Science. 2024;14:100163. doi: 10.1016/j.endmts.2024.100163
★ Most popular article in Endocrine and Metabolic Science in the past 3 years (May 2026)Mitochondrial Reactive Oxygen Species: A Unifying Mechanism in Long COVID and Spike Protein-Associated Injury
Lee E, Ozigbo AA, Varon J, Halma M, Laezzo M, Ang SP, Iglesias J. Mitochondrial reactive oxygen species: a unifying mechanism in long COVID and spike protein-associated injury. Biomolecules. 2025;15(9):1339. doi: 10.3390/biom15091339
Breaking the Silence: Recognizing Post-Vaccination Syndrome
Halma M, Varon J. Breaking the silence: recognizing post-vaccination syndrome. Heliyon. 2025;11(11):e43478. doi: 10.1016/j.heliyon.2025.e43478
★ Cited by the Advisory Committee on Immunization Practices (ACIP) COVID-19 Immunization WorkgroupMetabolic Modulation as a Therapeutic Strategy for Post-Acute Vaccination Syndrome (PACVS): A Review of Pathomechanisms and Existing Therapeutic Components
Halma M, Varon J. Metabolic modulation as a therapeutic strategy for post-acute vaccination syndrome (PACVS): a review of pathomechanisms and existing therapeutic components. Biomedicine & Pharmacotherapy. 2025;193:118864. doi: 10.1016/j.biopha.2025.118864
Autoimmunity, Vascular Dysfunction and Metabolic Alterations: A Trifecta of Impacts in Postacute COVID-19 Vaccination Syndrome (PACVS)
Halma M, Dhillon S, Gracidas C, Hassaan S, Bellavite P, Di Fede G, Varon J. Autoimmunity, vascular dysfunction and metabolic alterations: a trifecta of impacts in postacute COVID-19 vaccination syndrome (PACVS). IntechOpen. 2026. doi: 10.5772/intechopen.1245557
Lactate, Capnia, and Fat Oxidation as Therapeutic Axes for SARS-CoV-2 Spike Protein-Induced Sequelae
Gracidas C, Levy R, Varon J, Halma M. Lactate, capnia, and fat oxidation as therapeutic axes for SARS-CoV-2 spike protein-induced sequelae. Hormone and Metabolic Research. 2026. doi: 10.1055/a-2794-9646
The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury
Halma M, Vottero P, Thorp J, Peers T, Tuszynski J, Marik P. The possible mechanistic basis of individual susceptibility to spike protein injury. Advances in Virology. 2025. doi: 10.1155/av/7990876
Acute Management of Measles: A Systematic Review of Therapeutic Strategies
Kaur A, Alaribe U, Varon J, Hassaan S, Halma M. Acute management of measles: a systematic review of therapeutic strategies. Antiviral Research. 2026;247:106361. doi: 10.1016/j.antiviral.2026.106361
Restoring Trust in Vaccination: Listening to Patients and Acknowledging Post-Acute COVID Vaccine Syndrome
Halma M, Varon J. Restoring trust in vaccination: listening to patients and acknowledging post-acute COVID vaccine syndrome. Frontiers in Medicine. 2025;12:1688170. doi: 10.3389/fmed.2025.1688170
★ Cited by the Advisory Committee on Immunization Practices (ACIP) COVID-19 Immunization WorkgroupIdentifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses
Munshi S, Neupane K, Ileperuma SM, Halma MTJ, Kelly JA, Halpern CF, Dinman JD, Loerch S, Woodside MT. Identifying inhibitors of −1 programmed ribosomal frameshifting in a broad spectrum of coronaviruses. Viruses. 2022;14(2):177. doi: 10.3390/v14020177
Cancer Metabolism as a Therapeutic Target and Review of Interventions
Halma M, Tuszynski JA. Cancer metabolism as a therapeutic target and review of interventions. Nutrients. 2023;15(19):4245. doi: 10.3390/nu15194245
Lifestyle Medicine for Healthy Cognitive Aging: A Narrative Review
Halma M, Marik P, Gazda S, Tuszynski J. Lifestyle medicine for healthy cognitive aging: a narrative review. Brain, Behavior, and Immunity – Integrative. 2024;7:100077. doi: 10.1016/j.bbii.2024.100077
With Great Power Comes Great Responsibility: Promise and Caution in the New Psychedelic Renaissance
Halma M, Levy R, Varon J. With great power comes great responsibility: promise and caution in the new psychedelic renaissance. Brain Disorders. 2025;20:100286. doi: 10.1016/j.dscb.2025.100286
Therapeutic Potential of Herbalism for Opioid Use Disorder
Halma M, Hesse C, Selem E, Varon J. Therapeutic potential of herbalism for opioid use disorder. Revista Internacional de Investigación en Adicciones. 2025;11(1):71-78.
Blood Biomarkers Associated with All-Cause Mortality Risk: Accessibility and Clinical Utility for Lifestyle Medicine
Halma M, Aniwar M, Selem E, Tuszynski J, Varon J, Marik P. Blood biomarkers associated with all-cause mortality risk: accessibility and clinical utility for lifestyle medicine. Archives of Gerontology and Geriatrics Plus. 2025;2(2):100145. doi: 10.1016/j.aggp.2025.100145
Integrative Interventions for Improving Outcomes in Depression: A Narrative Review
Halma M, Plothe C, Marik PE. Integrative interventions for improving outcomes in depression: a narrative review. Psychology International. 2024;6(2):33. doi: 10.3390/psycholint6020033
From Biomarkers to Better Outcomes: Patient Empowerment Through Accessible Urine-Based Mortality Risk Tools — A Systematic Review
Selem E, Varon J, Halma MTJ. From biomarkers to better outcomes: patient empowerment through accessible urine-based mortality risk tools — a systematic review. Urological Science. 2025. doi: 10.1097/us9.0000000000000106
Herbal and Nutraceutical Interventions for Osteoporosis
Halma M, O'Leary C, Varon J. Herbal and nutraceutical interventions for osteoporosis: a review of effects on bone mineral density. Journal of Clinical Rheumatology and Immunology. 2025. doi: 10.1142/S2661341725300010
Beyond Targeted Therapy: Environmental Determinants and Metabolic Strategies in Cancer Prevention and Treatment
Halma M, Marik P, Varon J, Tuszynski J. Beyond targeted therapy: environmental determinants and metabolic strategies in cancer prevention and treatment. Annals of Research in Oncology. 2026;6(1):6-35. doi: 10.48286/aro.2026.122
Alleviating Age-Related Disease Burden
Halma M, Hassaan S, Tuszynski JA. Alleviating age-related disease burden. Frontiers in Aging. 2026;7:1828980. doi: 10.3389/fragi.2026.1828980
Guided Ensemble Stacking Method for Predicting Biological Activities of Compounds
Shamloo A, Tuszynski J, Tam Y, Tseng CY. Guided ensemble stacking method for predicting biological activities of compounds. Chemical Biology & Drug Design. 2025;106(6):e70230. doi: 10.1111/cbdd.70230
Beyond Gamma: Synergistic Potential of 10 Hz Alpha and 40 Hz Gamma Photobiomodulation in Alzheimer's Disease Treatment
Lim L, Staelens MA, Truglia B, Lazzari DD, Di Gregorio E, Shankar K, Liburd J, Hosseinkhah N, Karimpoor M, Tuszynski JA. Beyond gamma: synergistic potential of 10 Hz alpha and 40 Hz gamma photobiomodulation in Alzheimer's disease treatment. Alzheimer's & Dementia. 2025;21:e105314. doi: 10.1002/alz.70855
Effects of Light-Induced Electromagnetic Fields on Human Cancer Cells In Vitro
Truglia B, Castria S, Brown D, Lim L, de Wever B, Lewis J, Tuszynski JA. Effects of light-induced electromagnetic fields on human cancer cells in vitro. Bioelectricity. 2025;7(3):193-198. doi: 10.1177/25763113251376255
Computational Discovery of Potential Therapeutic Agents Against Brain-Eating Amoeba (Naegleria fowleri)
Zattoni J, Luduena RF, Aminpour M, Tuszynski JA. Computational discovery of potential therapeutic agents against brain-eating amoeba (Naegleria fowleri). PLOS ONE. 2025;20(7):e0327621. doi: 10.1371/journal.pone.0327621
Synergism or Mirage: Current Progress and an Empirical Approach for Elucidating Combination Drug Effects
Vottero P, Tuszynski JA, Tam YK, Tseng CY. Synergism or mirage: current progress and an empirical approach for elucidating combination drug effects. Drug Discovery Today. 2025;30(6):104381. doi: 10.1016/j.drudis.2025.104381
Designing of Potential siRNA Molecules for African Norovirus Gene Silencing: A Computational Approach
Ebenezer O, Oyebamiji AK, Olanrewaju AA, Akinola OT, Afolabi SO, Olaseinde AA, Tuszynski JA. Designing of potential siRNA molecules for African norovirus gene silencing: a computational approach. Pharmacological Research – Reports. 2025;3:100021. doi: 10.1016/j.pharep.2024.100021
External Low Energy Electromagnetic Fields Affect Heart Dynamics: Surrogate for System Synchronization, Chaos Control and Cancer Patient's Health
Costa FP, Tuszynski J, Iemma AF, Trevizan WA, Wiedenmann B, Schöll E. External low energy electromagnetic fields affect heart dynamics: surrogate for system synchronization, chaos control and cancer patient's health. Frontiers in Network Physiology. 2024;4:1525135. doi: 10.3389/fnetp.2024.1525135
A Systems Biology Analysis of Chronic Lymphocytic Leukemia
Pozzati G, Zhou J, Hazan H, Klement GL, Siegelmann HT, Tuszynski JA, Rietman EA. A systems biology analysis of chronic lymphocytic leukemia. Onco. 2024;4(3):13. doi: 10.3390/onco4030013
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases
Di Gregorio E, Staelens M, Hosseinkhah N, Karimpoor M, Liburd J, Lim L, Shankar K, Tuszynski JA. Raman spectroscopy reveals photobiomodulation-induced α-helix to β-sheet transition in tubulins: potential implications for Alzheimer's and other neurodegenerative diseases. Nanomaterials. 2024;14(13):1093. doi: 10.3390/nano14131093
Novel Combretastatin A-4 Analogs — Design, Synthesis, and Antiproliferative and Anti-Tubulin Activity
Jędrzejczyk M, Morabito B, Żyżyńska-Granica B, Struga M, Janczak J, Aminpour M, Tuszynski JA, Huczyński A. Novel combretastatin A-4 analogs — design, synthesis, and antiproliferative and anti-tubulin activity. Molecules. 2024;29(10):2200. doi: 10.3390/molecules29102200
Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors
Halma M. Alterations of SARS-CoV-2 evolutionary dynamics by pharmaceutical factors. Infectious Diseases & Immunity. 2024;4(1):35-40. doi: 10.1097/id9.0000000000000103
Overview of the Most Common Endocrine Disruptors: Exposure, Mechanism, Health Effects, and Remediation Strategies
Gracidas C, Selem E, Anyiam ND, Fertig B, Varon J, Halma M. Overview of the most common endocrine disruptors: exposure, mechanism, health effects, and remediation strategies. Environmental Toxicology. 2026. doi: 10.1002/tox.70066
The Search for Potential Remediation Strategies and Sustainable Alternatives for Safe Use of US EPA Superfund Sites
Donald AN, Sanders BL, Halma M. The search for potential remediation strategies and sustainable alternatives for safe use of US EPA Superfund sites. Trends in Ecological and Indoor Environmental Engineering. 2025;3(1):11-24. doi: 10.62622/teiee.025.3.1.11-24
★ Most viewed article of all time in Trends in Ecological and Indoor Environmental EngineeringFiat Lux: Light and Pedagogy for the 21st Century
Lech JC, Halma MTJ, Obajuluwa AO, Baker M, Hamblin MR. Fiat lux: light and pedagogy for the 21st century. Annals of Neurosciences. 2023;30(2):133-142. doi: 10.1177/09727531221136646
Towards Robust Pharmacovigilance Surveillance Systems
Halma M. Towards robust pharmacovigilance surveillance systems. One Health & Epidemiology. 2023. doi: 10.1515/ohe-2023-0033
The Persistence of COVID-19 Vaccine Artifacts in Bodily Fluids and Tissues: A Systematic Review
Selem E, Raszek M, Varon J, Halma M. The persistence of COVID-19 vaccine artifacts in bodily fluids and tissues: a systematic review. Future Journal of Pharmaceutical Sciences. 2026;12:16. doi: 10.1186/s43094-026-00939-2
DARE-SAFE: Denominator-Adjusted Rate Estimates of Substance Adverse Events Frequency Evaluation in Pharmaceuticals and Vaccines
Halma M, Varon J. DARE-SAFE: denominator-adjusted rate estimates of substance adverse events frequency evaluation in pharmaceuticals and vaccines. Pharmacoepidemiology. 2025;4(2):7. doi: 10.3390/pharmacoepidemiology4020007
Graphene-Based Nanomaterials: Uses, Environmental Fate, and Human Health Hazards
du Preez HN, Halma M. Graphene-based nanomaterials: uses, environmental fate, and human health hazards. Nano Biomedicine and Engineering. 2024;16(2):219-231. doi: 10.26599/nbe.2024.9290059
★ Most downloaded article of all time in Nano Biomedicine and EngineeringThe Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review
Halma MTJ, Rose J, Lawrie T. The novelty of mRNA viral vaccines and potential harms: a scoping review. J — Multidisciplinary Scientific Journal. 2023;6(2):220-235. doi: 10.3390/j6020017
★ #3 most viewed article of all time in J — Multidisciplinary Scientific Journal out of 317 articles (May 2026)Public Health Needs the Public Trust: A Pandemic Retrospective
Halma MTJ, Guetzkow J. Public health needs the public trust: a pandemic retrospective. BioMed. 2023;3(2):256-271. doi: 10.3390/biomed3020023
★ #3 most cited article of all time in BioMed out of 170 articles